| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T02777 | ||||
| Target Name | SUR2-type K(ATP) channel | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Repaglinide | Drug Info | Ki = 90 nMol/L | [552623] | |
| Glimepiride | Drug Info | IC50 = 7.3 nM | [552252] | ||
| References | |||||
| Ref 552623 | Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels. Diabetologia. 2006 Sep;49(9):2039-48. Epub 2006 Jul 25. | ||||
| Ref 552252 | Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. Br J Pharmacol. 2001 May;133(1):193-9. | ||||
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