| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T82146 | ||||
| Target Name | Retinoic acid receptor gamma | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Tazarotene | Drug Info | EC50 = 39 nM | [553242] | |
| Action against Disease Model | Tazarotene | IC50 on differentiation marker MRP-8 in normal h uMan keratinocytes: 7nM | [552181] | Drug Info | |
| References | |||||
| Ref 553242 | Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. | ||||
| Ref 552181 | Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. Cell Growth Differ. 1999 Apr;10(4):255-62. | ||||
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