| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T60366 | ||||
| Target Name | Ornithine decarboxylase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Eflornithine | Drug Info | Ki = 2200???000 nM | [553082] | |
| 3-methoxy-4-hydroxylonchocarpin | Drug Info | IC50 = 3600 nM | [525437] | ||
| 4-hydroxylonchocarpin | Drug Info | IC50 = 4700 nM | [525437] | ||
| ZAPOTIN | Drug Info | IC50 = 3400 nM | [528622] | ||
| LONCHOCARPUSONE | Drug Info | IC50 = 2600 nM | [525437] | ||
| 3-(Aminooxy)propan-1-amine hydrochloride | Drug Info | IC50 = 35 nM | [531018] | ||
| 1-Amino-3-(aminoxy)-2-propanol Dihydrochloride | Drug Info | IC50 = 39 nM | [531018] | ||
| References | |||||
| Ref 553082 | A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog. 2010 Nov 24;6(11):e1001204. doi: 10.1371/journal.ppat.1001204. | ||||
| Ref 525437 | J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide. | ||||
| Ref 525437 | J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide. | ||||
| Ref 528622 | J Med Chem. 2007 Jan 25;50(2):350-5.Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. | ||||
| Ref 525437 | J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide. | ||||
| Ref 531018 | Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. Epub 2010 Jun 17.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. | ||||
| Ref 531018 | Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. Epub 2010 Jun 17.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. | ||||
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