| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T11288 | ||||
| Target Name | Multidrug resistance-associated protein 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Sulfinpyrazone | Drug Info | IC50 = 420 uM | [552346] | |
| XR-9577 | Drug Info | IC50 = 320 nM | [529220] | ||
| XR-9504 | Drug Info | IC50 = 260 nM | [529220] | ||
| XR-9544 | Drug Info | IC50 = 50 nM | [529220] | ||
| L-660771 | Drug Info | IC50 = 7570 nM | [529644] | ||
| XR-9456 | Drug Info | IC50 = 300 nM | [529220] | ||
| References | |||||
| Ref 552346 | Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. | ||||
| Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
| Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
| Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
| Ref 529644 | Bioorg Med Chem Lett. 2008 Sep 1;18(17):4761-3. Epub 2008 Aug 3.A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins. | ||||
| Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
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