| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T13491 | ||||
| Target Name | Equilibrative nucleoside transporter 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine | Drug Info | Ki = 2200 nM | [527247] | |
| 9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine | Drug Info | Ki = 135 nM | [527247] | ||
| S6-nitrobenzyl mercaptopurine riboside | Drug Info | Ki = 0.7 nM | [529877] | ||
| LIDOFLAZINE | Drug Info | Ki = 279.9 nM | [528952] | ||
| N6-CYCLOPENTYLADENOSINE | Drug Info | Ki = 1100 nM | [527371] | ||
| References | |||||
| Ref 527247 | J Med Chem. 2004 Oct 21;47(22):5441-50.Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. | ||||
| Ref 527247 | J Med Chem. 2004 Oct 21;47(22):5441-50.Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. | ||||
| Ref 529877 | Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21. Epub 2008 Dec 6.Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. | ||||
| Ref 528952 | J Med Chem. 2007 Aug 9;50(16):3906-20. Epub 2007 Jul 18.Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. | ||||
| Ref 527371 | J Med Chem. 2005 Jan 13;48(1):321-9.Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. | ||||
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