Target Validation Information
Target ID T37847
Target Name DNA polymerase
Target Type
Successful
Drug Potency against Target DdCTP SODIUM Drug Info IC50 = 1300 nM [527652]
(+)-Myristinin A Drug Info Ki = 11000 nM [527897]
PENICILLIOL A Drug Info IC50 = 19800 nM [529967]
(+)-Myristinin D Drug Info Ki = 12000 nM [527897]
Mahureone D Drug Info IC50 = 12000 nM [527652]
3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid Drug Info IC50 = 2900 nM [525549]
TALAROFLAVONE Drug Info IC50 = 16300 nM [529247]
Gallic acid 5,6-dihydroxy-3-carboxyphenylester Drug Info Ki = 390 nM
Alpha,beta-methylene-dCTP Drug Info Ki = 900 nM [529712]
6-(4-Chloro-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 14100 nM [533563]
6-(4-Bromo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 4000 nM [533563]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 18600 nM [533563]
Alpha,beta-methylene-dTTP Drug Info Ki = 600 nM [529712]
Alpha,beta-methylene-dGTP Drug Info Ki = 1000 nM [529712]
Alpha,beta-methylene-dATP Drug Info Ki = 5000 nM [529712]
3-Oximo-olean-12-en-29-oic acid Drug Info IC50 = 16000 nM [525581]
(24E)-3beta-hydroxy-7,24-euphadien-26-oic acid Drug Info Ki = 2800 nM [525904]
References
Ref 527652J Nat Prod. 2005 Jul;68(7):979-84.Acylphloroglucinol derivatives from Mahurea palustris.
Ref 527897J Nat Prod. 2005 Nov;68(11):1625-8.(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
Ref 529967Bioorg Med Chem. 2009 Mar 1;17(5):1811-6. Epub 2009 Feb 1.Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.
Ref 527897J Nat Prod. 2005 Nov;68(11):1625-8.(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
Ref 527652J Nat Prod. 2005 Jul;68(7):979-84.Acylphloroglucinol derivatives from Mahurea palustris.
Ref 525549J Nat Prod. 1999 Jul;62(7):1000-2.Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata.
Ref 529247Bioorg Med Chem. 2008 Mar 15;16(6):2939-44. Epub 2007 Dec 25.1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 525581J Nat Prod. 1999 Aug;62(8):1110-3.DNA polymerase beta inhibitors from Sandoricum koetjape.
Ref 525904J Nat Prod. 2000 Oct;63(10):1356-60.A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta.

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