| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T05114 | ||||
| Target Name | Chymase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | Rac-2q | Drug Info | IC50 = 39 nM | [528779] | |
| CHYMOSTATIN | Drug Info | IC50 = 43 nM | [528779] | ||
| Delanzomib | Drug Info | IC50 = 3530 nM | [529283] | ||
| BOCEPREVIR | Drug Info | IC50 = 32 nM | [530459] | ||
| JNJ-10311795 | Drug Info | Ki = 2.3 nM | [528733] | ||
| References | |||||
| Ref 528779 | Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. Epub 2007 Mar 16.Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. | ||||
| Ref 528779 | Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. Epub 2007 Mar 16.Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. | ||||
| Ref 529283 | J Med Chem. 2008 Feb 28;51(4):1068-72. Epub 2008 Feb 5.Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. | ||||
| Ref 530459 | Antimicrob Agents Chemother. 2010 Jan;54(1):305-11. Epub 2009 Oct 19.MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. | ||||
| Ref 528733 | J Med Chem. 2007 Apr 19;50(8):1727-30. Epub 2007 Mar 16.Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. | ||||
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