| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T51426 | ||||
| Target Name | Bile acid receptor | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 12-O-deacetyl-12-epi-19-deoxy-21-hydroxyscalarin | Drug Info | IC50 = 2400 nM | [529138] | |
| AGN-34 | Drug Info | IC50 < 10 nM | [527690] | ||
| E-GUGGULSTERONE | Drug Info | IC50 = 4100 nM | [529138] | ||
| References | |||||
| Ref 529138 | J Nat Prod. 2007 Nov;70(11):1691-5. Epub 2007 Nov 8.Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity. | ||||
| Ref 527690 | J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications. | ||||
| Ref 529138 | J Nat Prod. 2007 Nov;70(11):1691-5. Epub 2007 Nov 8.Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity. | ||||
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