| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T12817 | ||||
| Target Name | 73-kDa molecular chaperone HSP73 | ||||
| Target Type | Research |
||||
| Drug Potency against Target | Adenosine triphosphate | Drug Info | IC50 = 17300 nM | [531262] | |
| NSC-119911 | Drug Info | IC50 = 2730 nM | [531262] | ||
| Gentamicin | Drug Info | IC50 = 140000 nM | [553009] | ||
| NSC-119913 | Drug Info | IC50 = 5580 nM | [531262] | ||
| References | |||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
| Ref 553009 | Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. FEBS Lett. 2010 Feb 19;584(4):645-51. doi: 10.1016/j.febslet.2009.12.021. Epub 2009 Dec 22. | ||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
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