| Drug General Information |
| Drug ID |
D0C9JJ
|
| Former ID |
DNCL002405
|
| Drug Name |
AR-12
|
| Drug Type |
Small molecular drug
|
| Indication |
Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86]
|
Phase 1 |
[522785],
[542919]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C26H19F3N4O
|
| InChIKey |
YULUCECVQOCQFQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
15008861, 22455284, 44144352, 77529760, 99436984, 124757004, 124966544, 125163809, 125335329, 131480760, 134222632, 134964418, 136367304, 136367847, 137248109, 137750678, 143499298, 144116327, 152234784, 152258252, 152344384, 160647088, 162011464, 162037439, 162205107, 163893414, 164159505, 172131582, 172650377, 174006452, 174530327, 174530328, 180096554, 186014822, 198945474, 223704779, 226877051, 242059900, 247295286, 249565685, 249871551, 252215975, 252438951
|
| Target and Pathway |
| Target(s) |
3-phosphoinositide dependent protein kinase-1 |
Target Info |
Modulator |
[1572591]
|
|---|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
|
|
mTOR signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Focal adhesion
|
|
T cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Insulin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Aldosterone-regulated sodium reabsorption
|
|
Toxoplasmosis
|
|
Hepatitis C
|
|
Proteoglycans in cancer
|
|
Endometrial cancer
|
|
Prostate cancer
|
|
Non-small cell lung cancer
|
|
Choline metabolism in cancer
|
|
PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
|
PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
p53 pathway
|
|
Ras Pathway
|
|
p53 pathway feedback loops 2
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
BCR signaling pathway
|
|
Insulin Pathway
|
|
TCR signaling in naï
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
TCR signaling in naï
|
|
FAS (CD95) signaling pathway
|
|
mTOR signaling pathway
|
|
CXCR4-mediated signaling events
|
|
IGF1 pathway
|
|
Class I PI3K signaling events
|
|
ErbB1 downstream signaling
|
|
IL8- and CXCR2-mediated signaling events
|
|
CXCR3-mediated signaling events
|
|
VEGFR1 specific signals
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Class I PI3K signaling events mediated by Akt
|
|
IL8- and CXCR1-mediated signaling events
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
FGF signaling pathway
|
|
TGF-beta receptor signaling
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Insulin Signalling
|
|
Reactome
|
GPVI-mediated activation cascade
|
|
PIP3 activates AKT signaling
|
|
Activation of AKT2
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
FCERI mediated NF-kB activation
|
|
Integrin alphaIIb beta3 signaling
|
|
CD28 dependent PI3K/Akt signaling
|
|
CTLA4 inhibitory signaling
|
|
G beta:gamma signalling through PI3Kgamma
|
|
VEGFR2 mediated vascular permeability
|
|
VEGFR2 mediated cell proliferation
|
|
CLEC7A (Dectin-1) signaling
|
|
RHO GTPases activate PKNs
|
|
Constitutive Signaling by AKT1 E17K in Cancer
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
Focal Adhesion
|
|
Cardiac Hypertrophic Response
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
PIP3 activates AKT signaling
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
TSH signaling pathway
|
|
TCR signaling
|
|
Signaling by Insulin receptor
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Costimulation by the CD28 family
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
| References |
| Ref 522785 | ClinicalTrials.gov (NCT00978523) Study of AR-12 (2-Amino-N-[4-[5-(2 Phenanthrenyl)-3-(Trifluoromethyl)-1H-pyrazol-1-yl] Phenyl]-Acetamide) in Adult Patients With Advanced or Recurrent Solid Tumors orLymphoma. U.S. National Institutes of Health. |
|---|
| Ref 542919 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8005). |
|---|
| Ref 1572591 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
|---|
