Drug Information

Drug General Information
Drug ID
D01SJC
Former ID
DIB007970
Drug Name
Transdur-sufentanil
Synonyms
Sufentanil transdermal patch
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [547327]
Company
Durect
Structure
Download
2D MOL

3D MOL
Formula
C28H38N2O9S
Canonical SMILES
CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC.C(C(=O)<br />O)C(CC(=O)O)(C(=O)O)O
InChI
1S/C22H30N2O2S.C6H8O7/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-10,17H,3,11-16,18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
OJCZPLDERGDQRJ-UHFFFAOYSA-N
PubChem Compound ID
65494
PubChem Substance ID
7847910, 8189718, 12013739, 14813309, 43122272, 50025385, 51069360, 57315532, 85273816, 103771146, 104333865, 124813335, 126423414, 135021481, 137243699, 144206432, 164233875, 164765147, 175266658, 210274959, 210280597, 224350207, 226426301, 241110091, 252481131
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [533518]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 547327Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015205)
Ref 533518[3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol. 1983 Feb 18;87(2-3):209-25.

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