Drug Information

Drug General Information
Drug ID
D0B6YB
Former ID
DIB003830
Drug Name
LE-SN38
Drug Type
Small molecular drug
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Phase 2 [532503]
Company
NeoPharm
Structure
Download
2D MOL

3D MOL
Formula
C22H20N2O5
Canonical SMILES
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)<br />O
InChI
1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
PubChem Compound ID
104842
PubChem Substance ID
13355, 515301, 622834, 10233636, 11430409, 12012598, 14805294, 14805295, 44434437, 49835447, 50028359, 50112971, 56311337, 56311445, 56311571, 56312630, 57337873, 71831605, 80486942, 87559919, 89360249, 92712502, 103220117, 103996165, 104373061, 126588659, 126625532, 126656661, 126666539, 127855413, 134340412, 134340540, 135062353, 135693781, 135710073, 136377612, 136897516, 136911131, 137138435, 142309355, 144115510, 152059852, 152164367, 152200177, 152245349, 162178284, 162223790, 163367112, 164178264, 164194982
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [532122]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 532503Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer. Cancer. 2013 Dec 15;119(24):4223-30.
Ref 532122Analysis of type of cell death induced by topoisomerase inhibitor SN-38 in human oral squamous cell carcinoma cell lines. Anticancer Res. 2012 Nov;32(11):4823-32.

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