Drug General Information
Drug ID	D06LRG
Former ID	DIB001593
Drug Name	TRV027
Indication	Heart failure [ICD9: 428; ICD10:I50]		Phase 2	[524481]
Company	Forest laboratories; trevena
Structure		Download 2D MOL
Target and Pathway
Target(s)	Type-1 angiotensin II receptor	Target Info	Antagonist	[532415]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Renin-angiotensin system
	Renin secretion
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway	Angiotensin Metabolism
	Muscle/Heart Contraction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Allograft Rejection
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524481	ClinicalTrials.gov (NCT01966601) A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure. U.S. National Institutes of Health.
Ref 532415	First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2013 Sep;53(9):892-9.

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