Drug Information

Drug General Information
Drug ID
D07BDY
Former ID
DIB015383
Drug Name
Tisocalcitate
Synonyms
SH-597; ZK-156942; Calcitriol analog (topical formulation), Schering AG
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [547723]
Company
Bayer Schering Pharma AG
Structure
Download
2D MOL

3D MOL
Formula
C31H48O5
Canonical SMILES
[C@@]12([C@H](/C(=C/C=C/3\C(=C)[C@H](C[C@@H](C3)O)O)/CC<br />C2)CC[C@@H]1[C@@H](/C=C/[C@H](C(C(=O)OC(C)C)(C)C)O)C)C
CAS Number
CAS 156965-06-9
PubChem Compound ID
9913924
Target and Pathway
Target(s) Vitamin D receptor Target Info Inhibitor [544140]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 547723Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018814)
Ref 544140The Rationale Behind Topical Vitamin D Analogs in the Treatment of Psoriasis: Where Does Topical Calcitriol Fit In?. J Clin Aesthet Dermatol. 2010 August; 3(8): 46-53.

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