Drug Information

Drug General Information
Drug ID
D0O0BR
Former ID
DIB003304
Drug Name
Poly-ICR
Synonyms
Poly-ICR (topical, keratosis/genital warts); Poly-ICR (topical, keratosis/genital warts), Akela; Poly-ICR (topical, keratosis/genital warts), Nventa; TLR-3 agonist (topical, acitinic keratosis/genital warts), Nventa; Poly IC-poly-arginine (topical, keratosis/genital warts), Nventa
Indication Keratosis [ICD10:L57.0] Investigative [543473]
Company
Nventa Biopharmaceuticals Corp
Target and Pathway
Target(s) Toll-like receptor 3 Target Info Agonist [543473]
KEGG Pathway Toll-like receptor signaling pathway
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Ligand-dependent caspase activation
MyD88-independent TLR3/TLR4 cascade
Trafficking and processing of endosomal TLR
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Cytosolic sensors of pathogen-associated DNA
Toll-Like Receptors Cascades
MyD88-independent cascade
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 543473(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).
Ref 543473(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).

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