Drug Information

Drug General Information
Drug ID
D03PBL
Former ID
DIB014737
Drug Name
PF-08
Synonyms
Amphetamine prodrug (tamper and abuse resistant, Bio-MD, ADHD), PharmacoFore; PF-08 (tamper and abuse-resistant/Bio-MD/prodrug, ADHD); PF-08 (tamper and abuse-resistant/Bio-MD/prodrug, ADHD), PharmacoFore
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Investigative [526471], [526676], [532175], [532852], [551871]
Company
PharmacoFore Inc
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Modulator [526471], [526676], [532175], [532852], [551871]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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