Drug Information

Drug General Information
Drug ID
D0W6EP
Former ID
DIB006255
Drug Name
AMG-889436
Synonyms
Metabotropic glutamate receptor 4 agonist (Parkinson's disease), Amgen; Metabotropic glutamate receptor 4 positive allosteric modulator (Parkinson's disease), Amgen
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Investigative [543830]
Company
Amgen Inc
Target and Pathway
Target(s) Glutamate receptor 4 Target Info Agonist [543830]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Amphetamine addiction
Nicotine addiction
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Reactome Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 543830(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
Ref 543830(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).

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