Drug Information

Drug General Information
Drug ID
D0GY4H
Former ID
DNCL001718
Drug Name
Taberminogene vadenovec
Synonyms
Trinam (TN)
Indication Vascular restinosis following vascular graft surgery [ICD10:T82.858A] Phase 3 [522657]
Company
Ark Therapeutics
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Modulator [532990]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Signaling by VEGF
References
Ref 522657ClinicalTrials.gov (NCT00895479) Adenovirus Vascular Endothelial Growth Factor (VEGF) Therapy in Vascular Access - Novel Trinam AGainst Control Evidence. U.S. National Institutes of Health.
Ref 532990Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci. 2014 Nov;35(11):604-20.

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