Drug Information

Drug General Information
Drug ID
D0Z8EJ
Former ID
DIB015131
Drug Name
KOS-1815
Synonyms
CRM1 and nuclear export inhibitors (cancer); KOS-1815; KOS-2385; KOS-2464; CRM1 and nuclear export inhibitors (cancer), Kosan
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Preclinical [548298]
Company
Kosan Biosciences Inc
Target and Pathway
Target(s) Exportin-1 Target Info Inhibitor [544432]
KEGG Pathway Ribosome biogenesis in eukaryotes
RNA transport
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathway Interaction Database Signaling events mediated by HDAC Class II
Canonical NF-kappaB pathway
Integrin-linked kinase signaling
Signaling events mediated by HDAC Class I
Role of Calcineurin-dependent NFAT signaling in lymphocytes
FoxO family signaling
Sumoylation by RanBP2 regulates transcriptional repression
Hedgehog signaling events mediated by Gli proteins
Regulation of nuclear beta catenin signaling and target gene transcription
Reactome Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
Mitotic Prometaphase
Cyclin A/B1 associated events during G2/M transition
WikiPathways Mitotic Metaphase and Anaphase
Signaling by TGF-beta Receptor Complex
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Host Interactions of HIV factors
Influenza Life Cycle
HIV Life Cycle
Mitotic Prometaphase
Mitotic G2-G2/M phases
References
Ref 548298Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024269)
Ref 544432Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.