Drug Information

Drug General Information
Drug ID
D0RD0Y
Former ID
DIB004049
Drug Name
RetinoStat
Synonyms
AngiStat; XiaGen; Cardiovascular disease therapy, Oxford Biomedica; Gene therapy (HRE), Oxford Biomedica; Angiostatin/endostatin gene therapy (LentiVector, AMD), Oxford Biomedica
Indication Macular degeneration [ICD9: 362.5; ICD10:H35.3] Phase 2 [531944]
Company
Oxford BioMedica plc
Target and Pathway
Target(s) Endostatin Target Info Modulator [531944]
Plasminogen Target Info Modulator [531944]
KEGG Pathway Protein digestion and absorptionhsa04080:Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Staphylococcus aureus infection
Influenza A
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database Beta1 integrin cell surface interactions
Direct p53 effectors
Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PathWhiz Pathway Coagulation
Reactome Collagen degradation
Activation of Matrix Metalloproteinases
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Laminin interactionsR-HSA-114608:Platelet degranulation
Degradation of the extracellular matrix
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways Assembly of collagen fibrils and other multimeric structures
Activation of Matrix Metalloproteinases
Collagen biosynthesis and modifying enzymesWP558:Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 531944Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(?), for age-related macular degeneration. Hum Gene Ther. 2012 Sep;23(9):980-91.
Ref 531944Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(?), for age-related macular degeneration. Hum Gene Ther. 2012 Sep;23(9):980-91.

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