Drug Information

Drug General Information
Drug ID
D00IDR
Former ID
DIB007096
Drug Name
Phenylalanine hydroxylase
Synonyms
Oralase; Phenylase; AvPAL-PEG; PEG-PAL; Phenylalanine hydroxylase, BioMarin; Phenylalanine hydroxylase, IBEX; Poly ethylene glycol-phenylalanine ammonia lyase; RAvPAL-PEG; Phenylketonuria therapy (enzyme), BioMarin
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 2 [522703]
Company
Biomarin pharmaceutical
CAS Number
CAS 9029-73-6
Target and Pathway
Target(s) Phenylalanine hydroxylase Target Info Modulator [532742]
BioCyc Pathway Phenylalanine degradation/tyrosine biosynthesis
KEGG Pathway Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of amino acids
PathWhiz Pathway Phenylalanine and Tyrosine Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
Abnormal metabolism in phenylketonuria
References
Ref 522703ClinicalTrials.gov (NCT00925054) Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU. U.S. National Institutes of Health.
Ref 532742Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet. 2014 Jul 5;384(9937):37-44.

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