Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R7EQ
|
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| Former ID |
DNCL001972
|
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| Drug Name |
Crenezumab
|
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| Synonyms |
MABT5102A; RG7412
|
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| Drug Type |
Monoclonal antibody
|
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| Company |
Genentech
|
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Modulator | [543619] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
| Ref 523453 | ClinicalTrials.gov (NCT01343966) A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY). U.S. National Institutes of Health. | ||||
| Ref 541978 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6934). | ||||
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