Drug Information

Drug General Information
Drug ID
D0A8EG
Former ID
DCL000653
Drug Name
TAK-591
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [548747]
Company
Takeda
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Antagonist [551717]
Type-1 angiotensin II receptor Target Info Antagonist [551717]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin systemhsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP554:ACE Inhibitor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Allograft Rejection
GPCR downstream signaling
References
Ref 548747Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028308)
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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