Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X3TI
|
||||
| Former ID |
DNCL002922
|
||||
| Drug Name |
SRT3025
|
||||
| Indication | Type 2 diabetes [ICD9: 250; ICD10:E11] | Phase 1 | [1] | ||
| Company |
Sirtris
|
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| Structure |
|
Download2D MOL |
|||
| Target and Pathway | |||||
| Target(s) | NAD-dependent deacetylase sirtuin-1 | Target Info | Modulator | [2] | |
| KEGG Pathway | FoxO signaling pathway | ||||
| AMPK signaling pathway | |||||
| Glucagon signaling pathway | |||||
| Amphetamine addiction | |||||
| MicroRNAs in cancer | |||||
| PANTHER Pathway | p53 pathway | ||||
| Pathway Interaction Database | p73 transcription factor network | ||||
| Signaling events mediated by HDAC Class III | |||||
| E2F transcription factor network | |||||
| HIF-2-alpha transcription factor network | |||||
| Signaling events mediated by HDAC Class I | |||||
| FoxO family signaling | |||||
| Regulation of Androgen receptor activity | |||||
| Regulation of retinoblastoma protein | |||||
| Reactome | RORA activates gene expression | ||||
| Regulation of HSF1-mediated heat shock response | |||||
| Circadian Clock | |||||
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| Integrated Breast Cancer Pathway | |||||
| SREBP signalling | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01340911) A Study in Healthy Male Volunteers to Investigate Different Doses of a New Drug for the Treatment of Metabolic Diseases. U.S. National Institutes of Health. | ||||
| REF 2 | The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One. 2015 Jul 30;10(7):e0134391. | ||||
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