Drug Information

Drug General Information
Drug ID
D0M4LW
Former ID
DIB005874
Drug Name
BIM-23268
Synonyms
BIM-23268D; L-Cysteinyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-cysteinamide cyclic-(1-8)-disulfide
Drug Type
Small molecular drug
Indication Acromegaly [ICD9: 253; ICD10:E22.0] Discontinued in Phase 2 [539319], [547475]
Structure
Download
2D MOL

3D MOL
Formula
C54H67N11O9S2
InChI
InChI=1S/C54H67N11O9S2/c1-32(66)46-54(74)63-43(27-35-19-9-4-10-20-35)52(72)64-45(47(57)67)31-76-75-30-38(56)48(68)60-41(25-33-15-5-2-6-16-33)50(70)61-42(26-34-17-7-3-8-18-34)51(71)62-44(28-36-29-58-39-22-12-11-21-37(36)39)53(73)59-40(49(69)65-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,58,66H,13-14,23-28,30-31,55-56H2,1H3,(H2,57,67)(H,59,73)(H,60,68)(H,61,70)(H,62,71)(H,63,74)(H,64,72)(H,65,69)/t32-,38+,40+,41+,42+,43+,44-,45+,46+/m1/s1
InChIKey
JNMPZUZCPFIJGJ-OCZUONHDSA-N
CAS Number
CAS 181650-80-6
PubChem Compound ID
5311026
PubChem Substance ID
7978792, 11056217, 14841548, 39340756, 50774903, 57359328, 114155085, 135289129, 135652037
Target and Pathway
Target(s) Somatostatin receptor Target Info Modulator [1572591]
References
Ref 539319(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2083).
Ref 547475Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016700)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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