Drug Information

Drug General Information
Drug ID
D03KST
Former ID
DIB015132
Drug Name
KT2-962
Synonyms
3-[4-(4-Chlorophenylsulfonamido)butyl]-6-isopropylazulene-1-sulfonic acid sodium salt
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Discontinued in Phase 1 [545314]
Structure
Download
2D MOL

3D MOL
Formula
C23H25ClNNaO5S2
Canonical SMILES
CC(C)C1=CC=C2C(=C(C=C2S(=O)(=O)[O-])CCCCNS(=O)(=O)C3=CC<br />=C(C=C3)Cl)C=C1.[Na+]
InChI
1S/C23H26ClNO5S2.Na/c1-16(2)17-6-12-21-18(15-23(32(28,29)30)22(21)13-7-17)5-3-4-14-25-31(26,27)20-10-8-19(24)9-11-20;/h6-13,15-16,25H,3-5,14H2,1-2H3,(H,28,29,30);/q;+1/p-1
InChIKey
QIBQVFYOTMPEIP-UHFFFAOYSA-M
PubChem Compound ID
23661969
PubChem Substance ID
15011185, 29309556, 51857828, 56038567, 103227145, 126437068, 135086502, 228985136
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [534176], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 545314Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002792)
Ref 534176Azulene derivatives as TXA2/PGH2 receptor antagonists--II. Synthesis and biological activity of 6-mono- and 6-dihydroxylated-isopropylazulenes. Bioorg Med Chem. 1996 Apr;4(4):575-91.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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