Drug Information

Drug General Information
Drug ID
D0L6KC
Former ID
DIB013164
Drug Name
BILR-355
Synonyms
BILR-355-BS; 11-Ethyl-5-methyl-8-[2-(1-oxidoquinolin-4-yloxy)ethyl]-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 2 [521806]
Structure
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2D MOL

3D MOL
Canonical SMILES
CCN1c2ncccc2N(C)C(=O)c3cc(CCOc4cc[n+]([O-])c5ccccc45)cn<br />c13
InChI
1S/C25H23N5O3/c1-3-29-23-19(25(31)28(2)21-9-6-12-26-24(21)29)15-17(16-27-23)11-14-33-22-10-13-30(32)20-8-5-4-7-18(20)22/h4-10,12-13,15-16H,3,11,14H2,1-2H3
InChIKey
BEMBRAMZGVDPMH-UHFFFAOYSA-N
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [531281], [551871]
References
Ref 521806ClinicalTrials.gov (NCT00294372) Phase II Study on the Antiviral Activity and Safety of BILR 355 BS in HIV-1 Infected, NNRTI-treated Patients. U.S. National Institutes of Health.
Ref 531281Evaluation of steady-state pharmacokinetic interactions between ritonavir-boosted BILR 355, a non-nucleoside reverse transcriptase inhibitor, and lamivudine/zidovudine in healthy subjects. J Clin Pharm Ther. 2012 Feb;37(1):81-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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