Drug Information

Drug General Information
Drug ID
D07OMK
Former ID
DIB014865
Drug Name
RO-48-6791
Synonyms
3-[5-(Dipropylaminomethyl)-1,2,4-oxadiazol-3-yl]-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [546337]
Structure
Download
2D MOL

3D MOL
Formula
C21H25FN6O2
Canonical SMILES
CCCN(CCC)CC1=NC(=NO1)C2=C3CN(C(=O)C4=C(N3C=N2)C=CC(=C4)<br />F)C
InChI
1S/C21H25FN6O2/c1-4-8-27(9-5-2)12-18-24-20(25-30-18)19-17-11-26(3)21(29)15-10-14(22)6-7-16(15)28(17)13-23-19/h6-7,10,13H,4-5,8-9,11-12H2,1-3H3
InChIKey
NOQIYRGMEFBZTI-UHFFFAOYSA-N
PubChem Compound ID
9953485
PubChem Substance ID
14928929, 24223298, 46050094, 79923261, 128732430, 134222191, 135257759, 233017286
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [534517]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 546337Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007556)
Ref 534517Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):477-86.

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