Drug Information

Drug General Information
Drug ID
D03RDQ
Former ID
DIB010135
Drug Name
Gavilimomab
Synonyms
ABX-CBL; CBL-1
Drug Type
Antibody
Indication Graft-versus-host disease [ICD9: 279.5; ICD10:T86.0] Phase 2/3 [521512]
Company
Abgenix Inc
CAS Number
CAS 244096-20-6
Target and Pathway
Target(s) Basigin Target Info [550396]
Pathway Interaction Database Syndecan-1-mediated signaling events
Reactome Degradation of the extracellular matrix
Basigin interactions
Integrin cell surface interactions
Pyruvate metabolism
WikiPathways The citric acid (TCA) cycle and respiratory electron transport
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Matrix Metalloproteinases
References
Ref 521512ClinicalTrials.gov (NCT00035880) Study Comparing ABX-CBL (Monoclonal Antibody) Versus Atgam in Patients With Steroid Resistant Acute Graft Versus Host Disease. U.S. National Institutes of Health.
Ref 550396National Cancer Institute Drug Dictionary (drug id 38221).

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