Drug General Information
Drug ID	D00IXN
Former ID	DIB008861
Drug Name	GS-6637
Indication	Substance dependence [ICD10:F10-F19]		Phase 1	[549559]
Structure		Download 2D MOL
Target and Pathway
Target(s)	Aldehyde dehydrogenase, mitochondrial	Target Info	Inhibitor	[531635], [550813]
KEGG Pathway	Glycolysis / Gluconeogenesis
	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Fatty acid degradation
	Valine, leucine and isoleucine degradation
	Lysine degradation
	Arginine and proline metabolism
	Histidine metabolism
	Tryptophan metabolism
	beta-Alanine metabolism
	Glycerolipid metabolism
	Pyruvate metabolism
	Metabolic pathways
	Biosynthesis of antibiotics
PathWhiz Pathway	Beta-Alanine Metabolism
	Ethanol Degradation
	Histidine Metabolism
	Valine, Leucine and Isoleucine Degradation
	Pyruvate Metabolism
	Oxidation of Branched Chain Fatty Acids
	Glycine and Serine Metabolism
	Tryptophan Metabolism
WikiPathways	Tryptophan metabolism
	Fatty Acid Omega Oxidation
	Phase 1 - Functionalization of compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 549559	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040688)
Ref 531635	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 550813	Clinical pipeline report, company report or official report of Gilead.

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