Drug General Information
Drug ID	D0FA6S
Former ID	DIB002760
Drug Name	Altiratinib
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[549538]
Company	Deciphera pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 2	Target Info	Antagonist	[550598]
	Angiopoietin 1 receptor	Target Info	Inhibitor	[550598]
	Hepatocyte growth factor receptor	Target Info	Inhibitor	[550598]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancerhsa04014:Ras signaling pathway
	HIF-1 signaling pathway
	Rheumatoid arthritishsa04014:Ras signaling pathway
	Axon guidance
	Adherens junction
	Bacterial invasion of epithelial cells
	Epithelial cell signaling in Helicobacter pylori infection
	Malaria
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Renal cell carcinoma
	Melanoma
	Central carbon metabolism in cancer
NetPath Pathway	IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathwayP00005:Angiogenesis
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
	SHP2 signalingmet_pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Arf6 signaling events
	Posttranslational regulation of adherens junction stability and dissassembly
	Direct p53 effectors
	Syndecan-1-mediated signaling events
	Stabilization and expansion of the E-cadherin adherens junction
	a6b1 and a6b4 Integrin signaling
	FGF signaling pathway
	Regulation of retinoblastoma protein
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-210993:Tie2 Signaling
	RAF/MAP kinase cascadeR-HSA-416550:Sema4D mediated inhibition of cell attachment and migration
WikiPathways	Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	AngiogenesisWP363:Wnt Signaling Pathway Netpath
	Cell surface interactions at the vascular wall
	AngiogenesisWP366:TGF beta Signaling Pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Extracellular vesicle-mediated signaling in recipient cells
	Signaling Pathways in Glioblastoma
	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Semaphorin interactions
References
Ref 549538	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040094)
Ref 550598	Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals.

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