Drug General Information
Drug ID	D01RBR
Former ID	DIB001234
Drug Name	SGS742
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Phase 2	[527226]
Company	Saegis Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Modulator	[527226]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527226	SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol. 2004 Oct 15;68(8):1479-87.
Ref 527226	SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol. 2004 Oct 15;68(8):1479-87.

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