Drug General Information
Drug ID	D0C4WY
Former ID	DIB013814
Drug Name	SP-08
Synonyms	SP-008
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Investigative	[543619]
Company	Georgetown University
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(ccc(c1OC)C(=O)N1CCN(CC1)CC)OC)OC
CAS Number	CAS 805251-89-2
Target and Pathway
Target(s)	Amyloid beta A4 protein	Target Info	Inhibitor	[543619]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
Reactome	Nuclear signaling by ERBB4
	Degradation of the extracellular matrix
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Alzheimers Disease
	Signalling by NGF
References
Ref 543619	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).
Ref 543619	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).

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