Drug General Information
Drug ID	D0PD1W
Former ID	DIB014639
Drug Name	Prostaglandin D2 antagonists
Synonyms	Laropiprant backup compounds, Merck & Co; Prostaglandin D2 antagonists, Merck & Co
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Investigative	[528672]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(cc(c2c(c1)c1c(n2[C@H](c2ccc(cc2)C(F)(F)F)C)[C@H](CCC<br />1)CC(=O)O)S(=O)(=O)C)F
Target and Pathway
Target(s)	Prostaglandin D2 receptor	Target Info	Antagonist	[543775]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528672	J Med Chem. 2007 Feb 22;50(4):794-806.Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Ref 543775	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 338).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.