Drug General Information
Drug ID	D04GHG
Former ID	DIB000011
Drug Name	Pim1 inhibitors
Synonyms	Pim1 inhibitors (cancer); Pim1 inhibitors (cancer), CNIO
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[552164]
Company	Centro Nacional de Investigaciones Oncologicas
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(nn2c(c1)ncc2C(=O)Nc1ccccc1)NCc1ccc(cc1)OC)C
Target and Pathway
Target(s)	Proto-oncogene pim-1	Target Info	Inhibitor	[543563]
KEGG Pathway	Jak-STAT signaling pathway
	MicroRNAs in cancer
	Acute myeloid leukemia
NetPath Pathway	IL9 Signaling Pathway
	IL5 Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
	Validated targets of C-MYC transcriptional activation
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IL5-mediated signaling events
	IL3-mediated signaling events
	C-MYB transcription factor network
WikiPathways	Ectoderm Differentiation
	Hematopoietic Stem Cell Differentiation
References
Ref 552164	WO patent application no. 2004058769, COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES.
Ref 543563	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).

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