Drug Information

Drug General Information
Drug ID
D09TPW
Former ID
DIB014529
Drug Name
PF-04475270
Synonyms
EP4 agonist (glaucoma), Pfizer; Prostaglandin E receptor 4 (EP4) agonist (glaucoma) Pfizer; CP-734432-prodrug (glaucoma), Pfizer
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Investigative [543780]
Company
Pfizer Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
C(F)(F)(c1cc(C[C@@H](CC[C@@H]2N(C(=O)CC2)CCCc2sc(cc2)C(<br />=O)O)O)ccc1)F
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [543780]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).
Ref 543780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).

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