Drug Information

Drug General Information
Drug ID
D04JPG
Former ID
DIB007977
Drug Name
PF-04447943
Synonyms
PDE 9 inhibitor (Alzheimer's disease); PDE 9 inhibitor (Alzheimer's disease), Pfizer; Phosphodiesterase 9 inhibitor (Alzheimer's disease), Pfizer
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Investigative [543409]
Company
Pfizer Inc
Structure
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2D MOL

3D MOL
Formula
C20H25N7O2
Canonical SMILES
C1(CCOCC1)n1c2nc([nH]c(=O)c2cn1)[C@H](N1CC(C1)Oc1ccccc1<br />)C
PubChem Compound ID
25115162
Target and Pathway
Target(s) Phosphodiesterase (PDE) 9 Target Info Inhibitor [543409]
KEGG Pathway Purine metabolism
Pathway Interaction Database Regulation of Androgen receptor activity
Reactome cGMP effects
References
Ref 543409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).
Ref 543409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).

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