Drug Information

Drug General Information
Drug ID
D04EPS
Former ID
DIB016246
Drug Name
ON-24160
Synonyms
Beta tubulin depolymerizer (cancer), Onconova; Beta-tubulin polymerization inhibitors (cancer), Onconova; ON-24 series (cancer), Onconova
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543674]
Company
Onconova Therapeutics Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(cc(c(cc1)OC)N)S(=O)(=O)N/C=C/c1c(cc(cc1OC)OC)OC
Target and Pathway
Target(s) Tubulin beta Target Info Inhibitor [543674]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 543674(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640).
Ref 543674(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640).

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