TTD | Drug: D0RC0H

Drug General Information
Drug ID	D0RC0H
Former ID	DIB016806
Drug Name	NPY Y5 antagonists
Synonyms	NPY Y5 antagonists (obesity, depression); NPY Y5 antagonists (obesity, depression), GlaxoSmithKline
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Investigative	[552083]
Company	GlaxoSmithKline plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cccc(c1F)n1ccc(NC[C@@H]2CC[C@@]3(OC(=O)N(c4cccnn4)C3)<br />CC2)n1
Target and Pathway
Target(s)	Neuropeptide Y receptor 5	Target Info	Antagonist	[543759]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552083	Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7120-3
Ref 543759	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 308).

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Drug Information