Drug Information

Drug General Information
Drug ID
D0T0LE
Former ID
DIB001852
Drug Name
IRX-4310
Synonyms
AGN-194310; AGN-4310; ALRT-4310; LGD-4310; NRX-4310; RARa antagonist (oral, chemotherapy-induced neutropenia), Io Therapeutics; Retinoic acid receptor alpha antagonist (oral, chemotherapy-induced neutropenia), Io Therapeutics
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 3 [546671]
Company
Io Therapeutics Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C1(=CC(Sc2c1cc(C#Cc1ccc(C(=O)O)cc1)cc2)(C)C)c1ccc(cc1)C<br />C
CAS Number
CAS 229961-45-9
Target and Pathway
Target(s) Retinoic acid receptor Target Info Antagonist [527142]
References
Ref 546671Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009573)
Ref 527142An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

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