Drug Information

Drug General Information
Drug ID
D0N6JF
Former ID
DIB001931
Drug Name
H-PGDS inhibitors
Synonyms
Hematopoietic prostaglandin D2 synthase inhibitors, Taiho; Prostanoid antagonists, Taiho; H-PGDS inhibitors (oral, allergy/inflammation); H-PGDS inhibitors (oral, allergy/inflammation), Taiho
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Investigative [552102]
Company
Taiho Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
C1CCCN1C(=O)c1oc(c(c2nc3cc(C(=O)c4ccccc4)ccc3[nH]2)c1C)<br />C
Target and Pathway
Target(s) Glutathione S-transferase Target Info Antagonist [543414]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
WikiPathways Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Integrated Pancreatic Cancer Pathway
References
Ref 552102Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95
Ref 543414(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1381).

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