| Drug General Information |
| Drug ID |
D0EU1R
|
| Former ID |
DIB012576
|
| Drug Name |
GSK-2334470
|
| Synonyms |
PDK1 inhibitors, GlaxoSmithKline
|
| Drug Type |
Small molecular drug
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
|---|
| Company |
GlaxoSmithKline plc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C25H34N8O
|
| InChI |
InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
|
| InChIKey |
QLPHOXTXAKOFMU-WBVHZDCISA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
96070189, 120480283, 131272728, 131344179, 138858687, 152258616, 160647451, 165247850, 172919056, 177748877, 180420926, 185990481, 223391038, 223705263, 224544156, 225373256, 227540026, 241376833, 249565688, 252157822, 252451499, 252471886
|
| Target and Pathway |
| Target(s) |
3-phosphoinositide dependent protein kinase-1 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
FoxO signaling pathway
|
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Sphingolipid signaling pathway
|
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mTOR signaling pathway
|
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PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Focal adhesion
|
|
T cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Neurotrophin signaling pathway
|
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Insulin signaling pathway
|
|
Thyroid hormone signaling pathway
|
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Aldosterone-regulated sodium reabsorption
|
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Toxoplasmosis
|
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Hepatitis C
|
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Proteoglycans in cancer
|
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Endometrial cancer
|
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Prostate cancer
|
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Non-small cell lung cancer
|
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Choline metabolism in cancer
|
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PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
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Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
|
PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
p53 pathway
|
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Ras Pathway
|
|
p53 pathway feedback loops 2
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
BCR signaling pathway
|
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Insulin Pathway
|
|
TCR signaling in naï
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
TCR signaling in naï
|
|
FAS (CD95) signaling pathway
|
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mTOR signaling pathway
|
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CXCR4-mediated signaling events
|
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IGF1 pathway
|
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Class I PI3K signaling events
|
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ErbB1 downstream signaling
|
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IL8- and CXCR2-mediated signaling events
|
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CXCR3-mediated signaling events
|
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VEGFR1 specific signals
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
|
Class I PI3K signaling events mediated by Akt
|
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IL8- and CXCR1-mediated signaling events
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
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FGF signaling pathway
|
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TGF-beta receptor signaling
|
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PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Insulin Signalling
|
|
Reactome
|
GPVI-mediated activation cascade
|
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PIP3 activates AKT signaling
|
|
Activation of AKT2
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
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FCERI mediated NF-kB activation
|
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Integrin alphaIIb beta3 signaling
|
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CD28 dependent PI3K/Akt signaling
|
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CTLA4 inhibitory signaling
|
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G beta:gamma signalling through PI3Kgamma
|
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VEGFR2 mediated vascular permeability
|
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VEGFR2 mediated cell proliferation
|
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CLEC7A (Dectin-1) signaling
|
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RHO GTPases activate PKNs
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
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TCR Signaling Pathway
|
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Insulin Signaling
|
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EGF/EGFR Signaling Pathway
|
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Focal Adhesion
|
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Cardiac Hypertrophic Response
|
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Fc epsilon receptor (FCERI) signaling
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
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PIP3 activates AKT signaling
|
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BDNF signaling pathway
|
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Interleukin-11 Signaling Pathway
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B Cell Receptor Signaling Pathway
|
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Signaling Pathways in Glioblastoma
|
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TSH signaling pathway
|
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TCR signaling
|
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Signaling by Insulin receptor
|
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Integrin-mediated Cell Adhesion
|
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GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Costimulation by the CD28 family
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8008). |
|---|
| REF 2 | Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9. |
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