Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J5SD
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| Former ID |
DIB008876
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| Drug Name |
Gamma-secretase modulators
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| Synonyms |
Gamma-secretase modulators (Alzheimer's disease); Gamma-secretase modulators (Alzheimer's disease), F Hoffmann-La Roche
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| Drug Type |
Small molecular drug
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [552106] | ||
| Company |
F Hoffmann-La Roche Ltd
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| Structure |
|
Download2D MOL |
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| Formula |
C26H24F3N3O3
|
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| Canonical SMILES |
CC(C)(c1nc(Nc2ccc(c3nc(ncc3)C)c(c2)OC)nc(c1)Cc1ccc(cc1)<br />Cl)O
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Modulator | [543619] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
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