Drug General Information
Drug ID	D07LWT
Former ID	DIB011807
Drug Name	FE-202767
Synonyms	Oxytocin agonists (erectile dysfunction), Ferring
Indication	Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4]		Phase 2	[525314]
Company	Ferring Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cccc2c1Nc1c(CN2C(=O)c2ccc(c(c2)C)CNC(=O)N2[C@@H](CCC2<br />)C(=S)N2CCN(CCC2)C)cnn1C
Target and Pathway
Target(s)	Oxytocin receptor	Target Info	Agonist	[543799]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Oxytocin signaling pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Oxytocin receptor mediated signaling pathway
Reactome	Vasopressin-like receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Myometrial Relaxation and Contraction Pathways
	Oxytocin signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 525314	ClinicalTrials.gov (NCT02545127) Trial Exploring the Efficacy and Safety of FE 202767.
Ref 543799	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369).

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