Drug Information

Drug General Information
Drug ID
D0H4BF
Former ID
DIB016289
Drug Name
NS-11757
Synonyms
NS-11757; NS-309; NS-4591; NS-6277; NS-8593; Calcium-activated potassium channel modulators, Neurosearch
Drug Type
Small molecular drug
Indication Atrial fibrillation [ICD9: 272, 427.31; ICD10:E78, I48] Investigative [539958]
Company
NeuroSearch A/S
Structure
Download
2D MOL

3D MOL
Formula
C17H15Cl2N3
InChI
InChI=1S/C17H15Cl2N3/c18-12-8-10-4-3-7-14(11(10)9-13(12)19)20-17-21-15-5-1-2-6-16(15)22-17/h1-2,5-6,8-9,14H,3-4,7H2,(H2,20,21,22)
InChIKey
JHLGZRSIUIFADK-UHFFFAOYSA-N
PubChem Compound ID
25102784
PubChem Substance ID
56424199, 84998190, 103647754, 104118675, 135650742
Target and Pathway
Target(s) Sulfonylurea receptor 1 Target Info Modulator [539957]
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas Function
Reactome ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolism
References
Ref 539958(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).
Ref 539957(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).

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