Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06EHW
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| Former ID |
DIB012323
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| Drug Name |
IAI-100
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| Synonyms |
ADAM inhibitors (cancer); IAI-100; IAI-102; INCB-3531; INCB-3619; A disintegrin and metalloprotease inhibitors (cancer), Incyte;ADAM inhibitors (cancer), Incyte; HER-2 sheddase inhibitors (cancer), Incyte
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Incyte Corp
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| Structure |
|
Download2D MOL |
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| Formula |
C22H27N3O5
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| InChI |
InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
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| InChIKey |
CKZHFOKQZRZCPF-ROUUACIJSA-N
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| CAS Number |
CAS 791826-72-7
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | ADAM 10 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Alzheimer's disease | ||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| NetPath Pathway | RANKL Signaling Pathway | ||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Pathway Interaction Database | Notch signaling pathway | ||||
| Presenilin action in Notch and Wnt signaling | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| WikiPathways | Hypertrophy Model | ||||
| Copper homeostasis | |||||
| Signaling by NOTCH3 | |||||
| Signaling by NOTCH4 | |||||
| Signaling by NOTCH2 | |||||
| Alzheimers Disease | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8679). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8679). | ||||
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