Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06MBR
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| Former ID |
DIB012217
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| Drug Name |
ACI-636
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| Synonyms |
Morphomers; ACI-140; Beta amyloid beta sheet formation inhibitor (CNS diseases), AC Immune; Beta-amyloid oligomer inhibitors (Alzheimer's disease), AC Immune
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [543619] | ||
| Company |
AC Immune SA
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(c2ccc(cc2)F)[nH]nc(c1)NCCNc1n[nH]c(c1)c1ccc(cc1)F
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Inhibitor | [543619] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
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