Drug General Information
Drug ID	D05APW
Former ID	DIB004157
Drug Name	ABT-116
Synonyms	A-1165442
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Investigative	[543861]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cc(c2c(c1)n(nc2)C)NC(=O)NCc1ccc(cc1CCC(C)(C)C)C(F)(F)<br />F
Target and Pathway
Target(s)	Vanilloid receptor 1	Target Info	Antagonist	[543861]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	TRP channels
References
Ref 543861	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).
Ref 543861	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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