Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V7GC
|
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| Former ID |
DIB008730
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| Drug Name |
Rolafagrel
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| Synonyms |
FCE-22178
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| Drug Type |
Small molecular drug
|
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| Indication | Nephritis [ICD10:N00-N19, N25-N29] | Discontinued in Phase 2 | [1] | ||
| Company |
Pharmacia & Upjohn AB
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| Structure |
|
Download2D MOL |
|||
| Formula |
C14H12N2O2
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| Canonical SMILES |
C1(=Cc2cc(C(=O)O)ccc2CC1)n1cncc1
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| CAS Number |
CAS 89781-55-5
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane-A synthase | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Platelet activation | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| Eicosanoid Synthesis | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001438) | ||||
| REF 2 | Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:707-10. | ||||
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