Drug General Information
Drug ID	D00BZS
Former ID	DIB010607
Drug Name	Gimatecan
Synonyms	LBQ-707; ST-1480; ST-1481; Camptothecin analogs, Sigma-Tau; 7-cyano-camptothecin
Drug Type	Small molecular drug
Indication	Breast cancer [ICD9: 174, 175; ICD10:C50]		Phase 2	[532152]
Company	Sigma-Tau Ind Farm Riunite SpA
Structure		Download 2D MOL 3D MOL
Formula	C25H25N3O5
Canonical SMILES	n12c(c3c(C2)c(c2c(n3)cccc2)/C=N/OC(C)(C)C)cc2c(c1=O)COC<br />(=O)[C@]2(O)CC
CAS Number	CAS 292618-32-7
PubChem Compound ID	9577124
Target and Pathway
Target(s)	Toposisomerase-1	Target Info	Inhibitor	[532255]
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	DNA replication
Pathway Interaction Database	Caspase Cascade in Apoptosis
WikiPathways	Integrated Pancreatic Cancer Pathway
References
Ref 532152	A phase II trial of oral gimatecan for recurrent glioblastoma. J Neurooncol. 2013 Feb;111(3):347-53.
Ref 532255	Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect. Biochem Pharmacol. 2013 May 15;85(10):1433-40.

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